When your child has adrenal insufficiency, every dose matters.

Daily treatment of adrenal insufficiency in children shouldn't feel complicated or uncertain. Two FDA-approved options are designed to support accurate, consistent replacement therapy, without pill splitting or compounding.

Two FDA-approved options

ALKINDI SPRINKLE hydrocortisone oral granules for pediatric adrenal insufficiency logo—available in 0.5mg, 1mg, 2mg, and 5mg strengths

For newborns and children
with adrenal insufficiency

The first hydrocortisone treatment designed for accurate dosing

  • Available in 0.5 mg, 1 mg, 2 mg, and 5 mg strengths
  • Granules can be given directly into the mouth or with soft food
  • No mixing, measuring, tablet splitting, or crushing required
  • Color-coded capsules for clear dose identification
Learn More About ALKINDI SPRINKLE

The only FDA-approved liquid hydrocortisone

  • Ready-to-use oral solution
  • No refrigeration or mixing required
  • Designed to support accurate daily dosing
  • Not for stress or acute event dosing
Learn More About KHINDIVI
KHINDIVI hydrocortisone oral solution logo. KHINDIVI is the only FDA-approved liquid hydrocortisone for children with adrenal insufficiency

For children 5 years and older
with adrenal insufficiency

No pill splitting required

pill splitting

No pill crushing required

pill crushing

No compounding required

compounding

Talk with your child's doctor about which option may be right for your family

The choice of ALKINDI SPRINKLE or KHINDIVI is based on your child’s unique situation and your doctor’s recommendation.

ALKINDI SPRINKLE hydrocortisone oral granules for pediatric adrenal insufficiency logo—available in 0.5mg, 1mg, 2mg, and 5mg strengths KHINDIVI hydrocortisone oral solution logo. KHINDIVI is the only FDA-approved liquid hydrocortisone for children with adrenal insufficiency

Eton Cares Program®

Your rare disease journey is personal.
So is our support.

When your doctor prescribes ALKINDI SPRINKLE or KHINDIVI, you're automatically enrolled in the Eton Cares Program. Here's what you can expect:

1 | Welcome call

Your Care Coordinator verifies your prescription, offers support, and answers any questions

2 | Insurance verification

Review coverage and benefits

3 | Financial assistance review

Explore copay programs and other support options

4 | Medication delivery

Instructions and product-specific information about medication delivery

5 | Ongoing pharmacy support

Pharmacy support including refill coordination, reminders, and 24/7 access to a pharmacist

6 | Nurse ambassador support

Help you and your child stay on track with treatment, answer health or medication questions, and provide regular check-ins by phone

For questions or support, please contact us at our
specialty pharmacy, Anovo®, at 1-833-343-2500

*Commercially eligible patients can pay $0 per month. Restrictions, limitations, and/or eligibility requirements may apply.

Frequently asked questions

Both are FDA-approved hydrocortisone replacement therapies for pediatric patients with adrenal insufficiency. ALKINDI SPRINKLE is an oral granule formulation available for newborns and children of all ages, in 4 premeasured strengths. KHINDIVI is a ready-to-use liquid oral solution approved for children 5 years of age and older. Your child's doctor will recommend the option that best fits your child's age, dose requirements, and daily routine.

Your child's doctor is your best guide. ALKINDI SPRINKLE is appropriate for newborns through older children. KHINDIVI is specifically approved for children 5 years of age and older. The right choice depends on your child's age, prescribed dose, and individual needs.

No. Both products are designed to be used as is. ALKINDI SPRINKLE granules can be sprinkled directly into the mouth or onto soft food. KHINDIVI is a ready-to-use liquid administered with an oral syringe provided through Anovo Specialty Pharmacy.

No. KHINDIVI is not approved for increased dosing during periods of stress or acute events. During these times, your child's doctor should switch to a different hydrocortisone-containing product and increase the dose as needed. Always follow your doctor's guidance.

Both ALKINDI SPRINKLE and KHINDIVI are dispensed through Anovo Specialty Pharmacy as part of the Eton Cares Program. Your Care Coordinator will assist with fulfillment after your child's prescription is received. For questions, call (833) 343-2500.

Commercially eligible patients can pay $0 per month. Enrollment in the Eton Cares Program is automatic when your child is prescribed either product. Restrictions, limitations, and/or eligibility requirements may apply.

Dedicated to children with congenital adrenal hyperplasia (CAH)

Eton Pharmaceuticals is focused on the specific needs of pediatric patients with CAH by developing FDA-approved hydrocortisone therapies designed to make accurate dosing simpler for children and the caregivers who manage their treatment.

ALKINDI SPRINKLE and KHINDIVI represent Eton's commitment to purpose-built solutions for this patient community, moving beyond the limitations of tablet splitting and compounded preparations.

USE AND IMPORTANT SAFETY INFORMATION FOR:

  • ALKINDI SPRINKLE® (hydrocortisone) oral granules and
  • KHINDIVI™ (hydrocortisone) 1 mg/mL oral solution

USE

ALKINDI SPRINKLE
ALKINDI SPRINKLE is a corticosteroid indicated for replacement therapy in pediatric patients with adrenocortical insufficiency.

KHINDIVI
KHINDIVI is a corticosteroid indicated as replacement therapy in pediatric patients 5 years of age and older with adrenocortical insufficiency.

Limitation of Use for KHINDIVI
KHINDIVI is not approved for increased dosing during periods of stress or acute events. Use a different hydrocortisone-containing drug product for stress dosing.

IMPORTANT SAFETY INFORMATION FOR ALKINDI SPRINKLE AND KHINDIVI

WHEN USING ALKINDI SPRINKLE OR KHINDIVI
Always give ALKINDI SPRINKLE or KHINDIVI exactly as your doctor has directed. Do not take ALKINDI SPRINKLE or KHINDIVI if you are allergic to hydrocortisone or any of its other ingredients.

Adrenal Crisis: Giving too low a dose or stopping medication can cause low levels of cortisol, which can result in serious illness or death. Treatment with intravenous hydrocortisone should be started immediately. When switching from another type of hydrocortisone to ALKINDI SPRINKLE or KHINDIVI, watch your child closely for any changes. If your child doesn’t get the entire dose of ALKINDI SPRINKLE because of vomiting or spitting some granules out, contact your doctor to see if another dose is needed. When taking KHINDIVI during periods of stress, such as infections or after surgery, your doctor should switch to another oral hydrocortisone product and increase the dose.

Immunosuppression and Increased Risk of Infection With Use of a Dosage Greater Than Replacement: Use of a greater than replacement dosage can suppress the immune system and increase the risks of new infections or exacerbation of latent infections with any pathogen, including viral, bacterial, fungal, protozoan, or helminthic infections.
Contact your healthcare provider if any infections develop.

Growth Retardation: The long-term use of corticosteroids in high doses may cause growth retardation in children.

Decrease in Bone Mineral Density: Corticosteroids can affect your child’s bone growth and strength.

Cushing’s Syndrome Due to High Doses of Corticosteroids: Treatment with high doses of corticosteroids can cause Cushing’s syndrome. Treatment should be limited to the smallest dose required, and your child’s growth and development monitored appropriately.

Psychiatric Changes: Corticosteroids can change your child’s behavior or mood. Tell your doctor if your child has periods of extreme happiness, extreme sadness, hallucinations, or depression.

Changes in Vision: Tell your doctor if your child has blurred vision or other vision problems during treatment with ALKINDI SPRINKLE or KHINDIVI.

Gastrointestinal Adverse Reactions: Tell the doctor if your child has stomach pain, upset stomach, black, tarry stools, or vomiting of blood. These could be signs of ulcers or tears in the stomach or intestines. Taking anti-inflammatory nonsteroidal drugs, like ibuprofen, naproxen, or aspirin, can increase the risk of ulcers or tears.

Vaccination: Administration of live vaccines may be acceptable in ALKINDI SPRINKLE-treated and KHINDIVI-treated pediatric patients with adrenocortical insufficiency who receive replacement corticosteroids.

ADDITIONAL IMPORTANT SAFETY INFORMATION FOR KHINDIVI

Systemic Adverse Reactions Due to Inactive Ingredients
Hyperosmolarity: KHINDIVI is not approved in children less than 5 years of age. The inactive ingredients in KHINDIVI can cause dangerous fluid imbalances.

Metabolic Acidosis and Other Adverse Reactions: Some ingredients in KHINDIVI may cause a buildup of acid in the body, low blood sugar, or injuries to the liver, kidneys, or brain that may increase the risk of adrenal crisis.

Laxative Effects Due to Inactive Ingredients: Some ingredients in KHINDIVI may cause stomach upset, resulting in vomiting and/or diarrhea and could increase the risk of adrenal crises in patients.

ADVERSE REACTIONS

The most common side effects of ALKINDI SPRINKLE or KHINDIVI include retaining fluids, changes in glucose tolerance, high blood pressure, behavioral and mood changes, greater appetite, and weight gain.

Additional side effects of KHINDIVI are reactions to inactive ingredients.

FOR ADDITIONAL INFORMATION ON ALKINDI SPRINKLE AND KHINDIVI
If you are being treated with ALKINDI SPRINKLE, please visit ALKINDISPRINKLE.com/patient for more information. If you are being treated with KHINDIVI, please visit KHINDIVI.com/patient for more information.

You are encouraged to report negative side effects of prescription drugs by contacting Eton Pharmaceuticals, Inc. at 1-855-224-0233 or the U.S. Food and Drug Administration (FDA) at www.fda.gov/safety/medwatch or call 1-800-FDA-1088.

Please see full Prescribing Information for more information on ALKINDI SPRINKLE and KHINDIVI.